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Researchers have found that Anti-aging It works in a protein deep within human cells.
Researchers at the Queensland Brain Institute (QBI) at the University of Queensland, Australia, have discovered that a protein, ATSF-1, controls the delicate balance between creating and repairing new damaged mitochondria, the part of the cell responsible for energy production.
“Mitochondrial dysfunction lies at the core of many human diseases, including common age-related diseases such as dementia and Parkinson’s disease,” said Associate Professor at Qatar International Institute Stephen Zorn.
While the energy produced by mitochondria powers biological functions, toxic byproducts of this process contribute to the aging process of the cell.
“Our discovery could have exciting implications for healthy aging and people with inherited mitochondrial diseases.
“In conditions of stress, when mitochondrial DNA is damaged, the ATSF-1 protein prioritizes repair that promotes cellular health and longevity,” Zorn said.
By analogy, Zorin likened the relationship to a race car that needs a pit stop.
“ATSF-1 makes the call that a cell breakpoint is needed when mitochondria; Need reforms.
“We studied ATFS-1 in C. elegans, or roundworms, and saw that enhancing its function promotes cellular health, which means the worms are leaner for longer.
“They didn’t live longer, but they were healthier as they got older,” Zorin said.
Understanding how cells promote repair is an important step toward identifying potential interventions to prevent mitochondrial damage, the authors said in the study, published in the journal Nature Cell Biology.
“Our goal is to extend the functions of tissues and organs that normally decline during aging by understanding how mitochondrial degradation contributes to this process,” said Michael Day, QBI.
We may eventually design interventions that preserve mitochondria DNA “Healthier for longer, better quality of life,” Day said.
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